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Why some people develop prediabetes: a practical look at common causes

Written By Lena Schmidt
Jul 16, 2026
Reviewed by   Maya Brooks, NP
Pilates instructor and anti-inflammatory diet enthusiast. I help women over 35 reclaim their energy through targeted movement and smart nutrition.
Why some people develop prediabetes: a practical look at common causes
Why some people develop prediabetes: a practical look at common causes Source: Glowthorylab

Prediabetes doesn’t announce itself with a bang. Most people who have it feel perfectly fine—no thirst, no fatigue, nothing obvious. That’s part of what makes it so common and so often missed. In the United States alone, more than one in three adults has prediabetes, and the majority don’t know it. Understanding why some people develop this condition and others don’t can help you make sense of your own health numbers—and what you might do about them.

Prediabetes is simply a signal: your blood sugar is higher than normal, but not yet high enough to be classified as type 2 diabetes. Think of it as a metabolic yellow light. The causes are a mix of biology, lifestyle, and sometimes sheer luck. Here’s a practical look at the key factors that tip the scale.

What actually happens inside the body?

At the core of prediabetes is a problem with insulin—the hormone that helps glucose move from your bloodstream into your cells for energy. Over time, your cells can become less responsive to insulin’s message. This is called insulin resistance. Your pancreas tries to compensate by pumping out more insulin, but eventually it can’t keep up. Blood sugar begins to creep upward, and you enter that gray zone. The process can unfold over years, and often the only clue is a routine blood test.

Body weight and where you carry it

Excess weight is one of the strongest predictors of prediabetes, but it’s not just about the number on the scale. Where your body stores fat matters considerably. Carrying extra weight around your abdomen—often measured by waist circumference—is closely tied to insulin resistance. Fat cells in the belly region are metabolically active: they release inflammatory compounds that can interfere with how your cells respond to insulin. Even a modest weight loss of 5 to 7 percent of your body weight can significantly lower your risk.

Physical inactivity and muscle health

Muscle is one of your body’s biggest consumers of glucose. When you’re sedentary, your muscles don’t pull as much sugar out of your blood. Over time, this contributes to higher fasting glucose levels. Regular movement—especially resistance training and brisk walking—improves your muscles’ sensitivity to insulin. That doesn’t mean you need to run marathons; even breaking up long periods of sitting can make a difference.

A 15-minute walk after meals has been shown to blunt post-meal blood sugar spikes more effectively than a single longer walk earlier in the day.

Your family history and genetics

You can do everything “right” and still have a higher risk if prediabetes or type 2 diabetes runs in your family. Genetics influence how your body produces insulin, how your cells respond to it, and how you store fat. People with a parent or sibling who has type 2 diabetes are at significantly increased risk. Race and ethnicity also play a role—prediabetes is more common among African American, Hispanic, Native American, and Asian American populations. These differences are partly genetic and partly shaped by social and environmental factors.

Sleep, stress, and the hidden hormones

Two underappreciated contributors: poor sleep and chronic stress. When you don’t get enough restful sleep, your body releases more cortisol and other stress hormones, which can directly raise blood sugar. Short sleep—less than six hours a night—has been linked to higher rates of prediabetes in large studies. Similarly, ongoing psychological stress keeps cortisol levels elevated, promoting insulin resistance. It’s not just about what you eat; it’s about how well you recover.

What about diet?

You have likely heard this before, but the pattern matters more than any single food. Diets high in refined carbohydrates—white bread, sugary cereals, sweetened drinks—cause rapid spikes in blood sugar that challenge your insulin system over time. Meanwhile, diets rich in fiber, vegetables, lean protein, and healthy fats tend to support stable glucose levels. One of the most impactful changes a person can make is reducing added sugars, especially in liquid form. Soda and sweetened coffee drinks deliver glucose without any fiber or protein to slow absorption.

Can prediabetes be reversed?

Yes. Prediabetes is not a life sentence. Many people return their blood sugar to normal ranges with consistent changes. The National Diabetes Prevention Program—a structured lifestyle intervention—has shown that losing a modest amount of weight, increasing physical activity, and making dietary shifts can cut the risk of progressing to type 2 diabetes by more than half. Some people also benefit from metformin, a medication that helps lower glucose production in the liver, but lifestyle changes remain the foundation.

The most practical takeaway: prediabetes is an early warning, not a diagnosis of failure. Knowing what pushes the needle—from belly fat to sleep habits—gives you specific levers to pull.

Related FAQs
The most common cause is insulin resistance, where your cells stop responding properly to insulin. This is often driven by excess body weight—especially abdominal fat—combined with physical inactivity.
Yes. While excess weight is a major risk factor, people of normal weight can develop prediabetes due to genetics, family history, high abdominal fat despite a normal BMI, poor diet, or sedentary habits.
Without intervention, many people with prediabetes develop type 2 diabetes within 5 to 10 years. However, lifestyle changes such as weight loss and increased physical activity can significantly reduce that risk or even reverse prediabetes.
Yes. Chronic stress raises cortisol and other stress hormones, which directly increase blood glucose and promote insulin resistance. Poor sleep also elevates these hormones, further compounding the problem.
Key Takeaways
  • Insulin resistance is the core metabolic problem in prediabetes, often driven by excess abdominal fat and inactivity.
  • Genetics and family history significantly increase risk, even in people with otherwise healthy habits.
  • Poor sleep and chronic stress raise cortisol, which directly elevates blood sugar.
  • Dietary patterns high in refined carbs and added sugars—especially sugary drinks—accelerate the progression.
  • Prediabetes can often be reversed through modest weight loss, consistent physical activity, and dietary changes.
Medical Note
This article is for informational purposse only and should not be taken asanb caring teotio ongpontyBeotot bacnts Spotiroeprofestional medical loloice. Awwver consux with a healthcart-professenar-tal for medical advice and ineatment.
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About the Author
Lena Schmidt
Healthy Aging Writer